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A recent study illustrated that supplementation of Beta-Alanine & Creatine increased maximal power output. It was concluded that it might be as a result of improved hydrogen ion buffering by elevated Carnosine concentrations. The use of Beta-Alanine to increase muscle Carnosine offers a way to increase anaerobic exercise potential and, is likely to add to the effects of Creatine in some exercise settings. First discovered in the early 1900’s, Beta-Alanine and Histidine are the two components of Carnosine. Histidine is already present in large quantity within skeletal muscles, so it is Beta-Alanine that acts as the rate-limiting factor in Carnosine conversion. Carnosine is very effective at buffering the Hydrogen ions responsible for producing the lactic acid burn. Studies have shown that increasing muscle Carnosine by supplementing Beta-Alanine may delay fatigue and improve the muscular aspects of athletic performance. Research also indicates that Beta-Alanine increases lactate threshold, improves the ability to maintain maximal power output during high-intensity exercise and decreases neuromuscular fatigue. By elevating Carnosine level, it may protect against damage to nerves, letting them fire at a faster rate than if they are injured. For example, instead of ones body operating at 80% the day after exercise, Carnosine may help it perform closer to the best possible levels. This is mainly useful for athletes who are constantly using the same muscles, without the ability to take a break and recover for a few days. The effects of creatine plus beta-alanine on strength, power, body composition, and endocrine changes were examined during a 10-wk resistance-training program in collegiate football players. Results of this study demonstrate the efficacy of creatine plus beta-alanine on strength performance. Creatine plus beta-alanine supplementation appeared to have the greatest effect on lean tissue accruement and body fat composition. Creatine Monohydrate has been proven through decades of research to enhance strength, endurance, and athletic performance. However some athletes have noted side effects including nausea, stomach cramps, bloating, and a host of other unwanted reactions. FREQUENTLY ASKED QUESTIONS: 1. What is the tingling feeling I am experiencing? Beta-Alanine is known to cause a niacin-like skin tingling reaction within minutes after it is consumed. This is perfectly normal and lessens with continued Beta-Alanine supplementation. It has best been described as the skin having begun to tingle or itch in certain spots. This is a normal body reaction to Beta-Alanine consumption. 2. Shouldn’t we take extra histidine along with Beta-Alanine since histidine is a component of carnosine? No, because histidine is already present in high concentrations in muscle, while Beta-Alanine is only present only in small amounts. Researchers have determined that it is beta-alanine that drives carnosine synthesis, not histidine. For the majority of healthy people, eating a well balance diet, histidine deficiency is very uncommon and no extra is needed to increase carnosine, just Beta-Alanine. I’ve heard that creatine monohydrate is the best kind of creatine to use. SELECTED REFERENCES: 1. HJ Green, Mechanisms of muscle fatigue in intense exercise. J Sports Sci. 1997Jun; 15(3):247-56. 2. RC Harris, Et. Al. The absorption of orally supplied beta-alanine and its effect onmuscle carnosine synthesis in human vastus lateralis. Amino Acids. May 30 2006. 3. RC Harris, Hill C, Wise JA. Effect of combined beta-alanine and creatine monohydrate supplementation on exercise performance. Medicine & Science in Sports & Exercise. 35(5) Supplement 1:S218, May 2003. 4. CA Hill, Et. Al. Influence of beta-alanine supplementation on skeletal musclecarnosine concentrations and high intensity cycling capacity. Amino Acids. July28 2006. 5. J Hoffman, Ratamess N, Kang J, Mangine G, Faigenbaum A, Stout J. Effect ofcreatine and beta-alanine supplementation on performance and endocrine responses in strength/power athletes. Int J Sport Nutr Exerc Metab. 2006 Aug;16(4): 430-46. 6. JR Stout, J.T. Cramer, M. Mielke, J. O’Kroy, D.J. Torok, and R.F. Zoeller. Effects of twenty-eight days of beta-alanine and creatine monohydrate supplementation on the physical working capacity at neuromuscular fatigue threshold. J. Strength Cond. Res. 20(4): 928–931. 2006. 7. Y Suzuki, Ito O, Mukai N, Takahashi H, Takamatsu K. High level of skeletal muscle carnosine contributes to the latter half of exercise performance during 30-smaximal cycle ergometer sprinting. Jpn J Physiol. 2002 Apr; 52(2): 199-205. 8. T Nagasawa Et. Al. In vitro and in vivo inhibition of muscle lipid and proteinoxidation by carnosine. Molecular and Cellular Biochemistry. September 2001. 9. RF Zoeller RF, Stout JR, O'kroy JA, Torok DJ, Mielke M. Effects of 28 days of beta-alanine and creatine monohydrate supplementation on aerobic power,ventilatory and lactate thresholds, and time to exhaustion. Amino Acids. 2006Sep 5; [Epub ahead of print]. [product_disclaimer]